S5197
Monoclonal Anti-SNX4 antibody produced in mouse
~2.0 mg/mL, clone SN43, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-Sorting Nexin 4
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
SN43, monoclonal
Application:
ELISA (i), ICC, WB
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
SN43, monoclonal
form
buffered aqueous solution
mol wt
antigen ~52 kDa
species reactivity
human
concentration
~2.0 mg/mL
technique(s)
immunocytochemistry: suitable, indirect ELISA: suitable, western blot: 2-4 μg/mL using total cell extract of SNX4-GFP transfected HEK-293T cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SNX4(8723)
General description
Monoclonal Anti-SNX4 (mouse IgG1 isotype) is derived from the hybridoma SN43 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Sorting Nexins 4 (SNX4) protein belongs to the sorting nexins (SNX) family. This protein contains an SNX pho homology (PX) domain (SNX-PX) and a Bin/Amphiphysin/Rvs (BAR) domain. The SNX4 gene is located on the human chromosome at 3q21.2.
Immunogen
Synthetic peptide corresponding to amino acids 7-24 of human SNX4.
Application
Monoclonal Anti-SNX4 antibody produced in mouse may be used in:
- immunoblotting
- immunocytochemistry
- enzyme-linked immunosorbent assay (ELISA)
Biochem/physiol Actions
Monoclonal Anti-SNX4 reacts specifically with human SNX4.
Sorting Nexins 4 (SNX4) protein interacts with various tyrosine kinase receptors. SNX4 protein and amphiphysin 2 interact in the cell cytosol and on cytoplasmic vesicular structures. Overexpression of the SNX4 gene blocks the endocytosis of the transferrin receptor as efficiently as amphiphysin 2. The SNX4/amphiphysin 2 complex is essential for the control of the endosome fate after the formation of the endocytic vesicle.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For extended storage, freeze at -20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discard if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Jez Carlton et al.
Traffic (Copenhagen, Denmark), 6(2), 75-82 (2005-01-07)
The sorting nexins (SNXs) are a family of PX domain-containing proteins found in yeast and mammalian cells that have been proposed to regulate intracellular trafficking. Mammalian SNXs have been suggested to function variously in pro-degradative sorting, internalization, endosomal recycling, or
Dheeraj Malhotra et al.
Neuron, 72(6), 951-963 (2011-12-27)
While it is known that rare copy-number variants (CNVs) contribute to risk for some neuropsychiatric disorders, the role of CNVs in bipolar disorder is unclear. Here, we reasoned that a contribution of CNVs to mood disorders might be most evident
R D Teasdale et al.
The Biochemical journal, 358(Pt 1), 7-16 (2001-08-04)
Sorting nexin 1 (SNX1), a peripheral membrane protein, has previously been shown to regulate the cell-surface expression of the human epidermal growth factor receptor [Kurten, Cadena and Gill (1996) Science 272, 1008-1010]. Searches of human expressed sequence tag databases with
Corinne Leprince et al.
Journal of cell science, 116(Pt 10), 1937-1948 (2003-04-02)
Endocytosis is a regulated physiological process by which membrane receptors and their extracellular ligands are internalized. After internalization, they enter the endosomal trafficking pathway for sorting and processing. Amphiphysins consist of a family of proteins conserved throughout evolution that are
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