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About This Item
Empirical Formula (Hill Notation):
C12H10Cl2N2O5PSNa
CAS Number:
Molecular Weight:
419.15
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥98% (HPLC)
form
solid
color
white
solubility
H2O: 1 mM
DMSO: freely soluble
ethanol: freely soluble
shipped in
dry ice
storage temp.
−70°C
SMILES string
[Na+].O[C@@H]1[C@@H]2O[P@]([S-])(=O)OC[C@H]2O[C@H]1n3cnc4cc(Cl)c(Cl)cc34
Application
Sp 5,6-DCl-cBIMPS may be used in cAMP-dependent protein kinase-mediated cell signaling studies.
Biochem/physiol Actions
Selective cAMP-dependent protein kinase (PKA) activator. Especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian cPDE types I & III and only extremely slowly hydrolized by cPDE type II. Surpasses the widely used but problematic dibutyryl cAMP or 8-CPT-cAMP in terms of metabolic stability, membrane permeability and potency.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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