S6076
Siomycin A
from Streptomyces sioyaensis, ≥98% (HPLC)
Synonym(s):
Antibiotic 6741-21, Mutabillicin, Mutabilycin, Sporangiomycin
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About This Item
Empirical Formula (Hill Notation):
C71H81N19O18S5
CAS Number:
Molecular Weight:
1648.84
NACRES:
NA.77
UNSPSC Code:
12352200
biological source
Streptomyces sioyaensis
assay
≥98% (HPLC)
solubility
DMSO: complete 10 mg/ml, clear, colorless to faintly yellow, DMSO: soluble
storage temp.
−20°C
Quality Level
General description
Siomycin A is a member of the thiazole antibiotics family.
Application
Siomycin A from Streptomyces sioyaensis yields clear, colorless to faint yellow solution in DMSO at 10 mg/ml.
Siomycin A from Streptomyces sioyaensis may be used in cell signaling studies.
Siomycin A has been used as a forkhead box protein M1 (FOXM1) inhibitor to study the effect of pharmacological inhibition of FOXM1 on isocitrate dehydrogenases 1 (IDH1) protein levels.
Biochem/physiol Actions
Siomycin A is a macrocyclic antibiotic with potent and selective antibacterial activity against gram negative and gram positive bacteria, including Mcobacterium tuberculosis and other clinical resistant strains. Siomycin inhibits antibody production and also inhibits the oncogenic transcription factor forkhead box M1 (FoxM1). Siomycin A has been shown to reduce anchorage-independent growth of cells in soft agar. Moveover in vitro asays show that Siomycin A selectively induces apoptosis of transformed, but not normal cells.
Siomycin A is a macrocyclic antibiotic with potent and selective antibacterial activity.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Uppoor G Bhat et al.
PloS one, 4(8), e6593-e6593 (2009-08-13)
Proteasome inhibitors are currently in the clinic or in clinical trials, but the mechanism of their anticancer activity is not completely understood. The oncogenic transcription factor FoxM1 is one of the most overexpressed genes in human tumors, while its expression
Tomonori Mori et al.
Chemistry, an Asian journal, 3(6), 1013-1025 (2008-05-09)
The total synthesis of siomycin A (1), a representative compound of the thiostrepton family of peptide antibiotics, was achieved by incorporating the five synthetic segments A (2), B (3), C (4), D (5), and E (6). The dehydropiperidine segment A
The structure of siomycin-D1, peptide antibiotic isolated from Streptomyces sioyaensis.
K Tokura et al.
The Journal of antibiotics, 33(12), 1563-1567 (1980-12-01)
FoxM1: a potential drug target for glioma.
Yu Li et al.
Future oncology (London, England), 8(3), 223-226 (2012-03-14)
Marianna Halasi et al.
Cell cycle (Georgetown, Tex.), 8(12), 1966-1967 (2009-05-05)
Oncogenic transcription factor FoxM1 represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Previously, we identified the thiazole antibiotics as potent inhibitors of FoxM1. Surprisingly, investigation of the mechanism
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