Skip to Content
Merck
CN

S6445

S-2E

≥98% (HPLC), powder

Synonym(s):

(S)-(+)-4-[1-(4-tert-Butylphenyl)-2-oxo-pyrrolidin-4-yl]methoxybenzoic acid

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C22H25NO4
CAS Number:
155730-92-0
Molecular Weight:
367.44
NACRES:
NA.77
PubChem Substance ID:
24724620
UNSPSC Code:
12352202
MDL number:
MFCD06407742

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI

1S/C22H25NO4/c1-22(2,3)17-6-8-18(9-7-17)23-13-15(12-20(23)24)14-27-19-10-4-16(5-11-19)21(25)26/h4-11,15H,12-14H2,1-3H3,(H,25,26)/t15-/m0/s1

SMILES string

CC(C)(C)c1ccc(cc1)N2C[C@@H](COc3ccc(cc3)C(O)=O)CC2=O

InChI key

YZADMDZNVOBYGR-HNNXBMFYSA-N

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: 11 mg/mL, H2O: insoluble

storage temp.

−20°C

Application

S-2E may be used in cell signaling studies.

Biochem/physiol Actions

HMG-CoA reductase and acetyl-CoA carboxylase inhibitor.
HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. In the liver, S-2E is converted into its active metabolite, S-2E-CoA. S-2E-CoA noncompetitively inhibited the enzymatic activities of both 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase and acetyl-CoA carboxylase at K(i)=18.11 microM and K(i)=69.2 microM, respectively.

Packaging

Shipped ambient under nitrogen.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
085K4624V
0000011525
085K4624

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

Fatty Acid Synthesis in Cancer Cells

Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service