S7029
[Pro9]-Substance P
≥97% (HPLC)
Synonym(s):
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Pro-Leu-Met-NH2
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About This Item
Empirical Formula (Hill Notation):
C66H102N18O13S
CAS Number:
Molecular Weight:
1387.69
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
CSCCC(NC(=O)C(CC(C)C)NC(=O)C1CCCN1C(=O)C(Cc2ccccc2)NC(=O)C(Cc3ccccc3)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C4CCCN4C(=O)C(CCCCN)NC(=O)C5CCCN5C(=O)C(N)CCCNC(N)=N)C(N)=O
assay
≥97% (HPLC)
storage temp.
−20°C
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
涉药品监管产品
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M Saffroy et al.
Brain research, 633(1-2), 317-325 (1994-01-07)
Due to the existence of differences in the pharmacological properties of tachykinin NK-1 receptors in the rat and the guinea pig, the autoradiographic distribution of NK-1 binding sites was compared in the brain of the two species using the selective
S Sagan et al.
Biochemical and biophysical research communications, 282(4), 958-964 (2001-05-16)
The internalization of [3H]propionyl[Met(O2)11]SP(7-11) which binds one binding site and of [3H][Pro9]SP which binds the two binding sites associated with the NK-1 receptor has been examined in CHO cells. The quantity of [3H][Pro9]SP measured inside the cytoplasm in kinetic experiments
F Petitet et al.
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 314(7), 299-303 (1992-03-26)
[Pro9]SP and septide have been described as selective agonists for the SP receptor (NK-1 type). These two peptides contract with a great efficacy the guinea-pig ileum, but unexpectedly septide was practically devoid of affinity for the NK-1 site labelled by
U Liminga et al.
Behavioural brain research, 57(1), 93-99 (1993-10-21)
Bilateral intranigral infusions of three different peptide agonists were made in rats exposed to fluphenazine decanoate, 30 mg/kg/month (FLU) or vehicle (CON) for seven months. Oral movements were monitored repeatedly during the neuroleptic pretreatment period, as well as before the
S Ravard et al.
Brain research, 651(1-2), 199-208 (1994-07-18)
Potent and selective NK-1 and NK-2 agonists as well as compounds with lower selectivity and affinity for NK-1 binding sites were compared in their ability to produce scratching and grooming behaviours when injected intracerebroventricularly in mice. Septide, an agonist with
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