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S7067

SB 202190

Name: SB 202190
Brand: SIGMA

≥98% (HPLC), powder, p38 MAP kinase inhibitor

Synonym(s):

4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₄FN₃O

CAS Number:

152121-30-7

Molecular Weight:

331.34

UNSPSC Code:

12352200

PubChem Substance ID:

24278272

NACRES:

NA.77

MDL number:

MFCD00941964

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

SB 202190, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

faintly yellow, to beige

solubility

DMSO: 10 mg/mL, clear

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4

InChI

1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)

InChI key

QHKYPYXTTXKZST-UHFFFAOYSA-N

Gene Information

human ... MAPK14(1432)

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Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

General description

SB202190 aids in enhancing the self-renewal ability of neural stem cells fromNPC1-deficient mice.

Application

SB 202190 has been used:

to investigate the role of p38mitogen-activated protein kinase (MAPK) signaling in establishment of reovirus infection
as a p38α inhibitor in in vivo studies to study its impact on the development or progression of adenocarcinoma in the colon mucosa tissues of APC ^Min/+mice.
as a component of basic BC medium to culture basal progenitor cells.
as a component of normal endometrium and endometrial tumor media for organoid culture.

SB 202190 was used to inhibit p38 activation in MCF7 cells⁵, mouse macrophages⁶ and HepG2 cells.⁷

Biochem/physiol Actions

SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase. SB 202190 binds within the ATP pocket of the active kinase (K_d = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from GlaxoSmithKline

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000538384

0000519748

0000487386

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NPC1 gene deficiency leads to lack of neural stem cell self-renewal and abnormal differentiation through activation of p38 mitogen-activated protein kinase signaling

Yang SR, et al.

Journal of Separation Science, 24(2), 292-298 (2006)

Protocol for generating airway organoids from 2D air liquid interface-differentiated nasal epithelia for use in a functional CFTR assay

Rodenburg LW, et al.

STAR protocols, 4(3), 102337-102337 (2023)

p38 Mitogen-Activated Protein Kinase Signaling Enhances Reovirus Replication by Facilitating Efficient Virus Entry, Capsid Uncoating, and Postuncoating Steps

Mohamed A, et al.

American journal of virology, 97(2), e0000923-e0000923 (2023)

Uncoupling p38? nuclear and cytoplasmic functions and identification of two p38? phosphorylation sites on ?-catenin: implications for the Wnt signaling pathway in CRC models

Lepore Signorile M, et al.

Journal of Separation Science, 13(1), 223-223 (2023)

Shedding of the Mer tyrosine kinase receptor is mediated by ADAM17 protein through a pathway involving reactive oxygen species, protein kinase Cδ, and p38 mitogen-activated protein kinase (MAPK).

Edward Thorp et al.

The Journal of biological chemistry, 286(38), 33335-33344 (2011-08-11)

Mer tyrosine kinase (MerTK) is an integral membrane protein that is preferentially expressed by phagocytic cells, where it promotes efferocytosis and inhibits inflammatory signaling. Proteolytic cleavage of MerTK at an unidentified site leads to shedding of its soluble ectodomain (soluble

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Global Trade Item Number

SKU	GTIN
S7067-5MG	04061836959784
S7067-25MG	04061836959777

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