S7321
Sphingosine Kinase 2 human
recombinant, expressed in baculovirus infected insect cells, aqueous glycerol solution
Synonym(s):
SPHK2
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About This Item
recombinant
expressed in baculovirus infected insect cells
form
aqueous glycerol solution
specific activity
20 units/μg
mol wt
70 kDa
UniProt accession no.
relevant disease(s)
arthritis
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... SPHK2(56848)
General description
The activation of sphingosine kinase plays a role in the pathogenesis of transplant arteriosclerosis.
Application
Sphingosine kinase 2 has been used in a study to assess novel therapeutic targets for rheumatoid arthritis. Sphingosine kinase 2 has also been used in a study to determine that crowding induces live cell extrusion, which maintains homeostatic cell numbers in epithelia .
Biochem/physiol Actions
Converts sphingosine to sphingosine-1-phosphate. SPHK2 shares two large conserved regions with SPHK1. While SPHK1 is found only in the cytosol, SPHK2 is localized in both the cytosol and nuclei.
Physical form
Supplied at 1.0 mg/ml in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween 20, 10% glycerol, 3 mM DTT.
Other Notes
One unit will produce 1.0 pmol of sphingosine-1-phosphate per minute at pH 7.5, 25 °C.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Regulatory Information
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Wen-Qi Lai et al.
Future medicinal chemistry, 4(6), 727-733 (2012-04-26)
Rheumatoid arthritis (RA) is a chronic, destructive, autoimmune joint disease characterized by elevated levels of proinflammatory cytokine production. Sphingosine kinase (SphK) phosphorylates sphingosine into sphingosine-1-phosphate. Synovial fluid of RA patients exhibits significantly higher levels of S1P than their non-inflammatory osteoarthritis
Qiurong Li et al.
Transplantation, 93(10), 989-996 (2012-04-03)
Transplant arteriosclerosis is a major cause of late intestinal allograft dysfunction. However, little is known about the immunologic and molecular mechanisms underlying it, and no effective treatment is available. This study aimed to investigate the role of sphingosine kinase 1
George T Eisenhoffer et al.
Nature, 484(7395), 546-549 (2012-04-17)
For an epithelium to provide a protective barrier, it must maintain homeostatic cell numbers by matching the number of dividing cells with the number of dying cells. Although compensatory cell division can be triggered by dying cells, it is unknown
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