S7947
Stattic
≥98% (HPLC), STAT3 activation inhibitor, powder
Synonym(s):
6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
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About This Item
Empirical Formula (Hill Notation):
C8H5NO4S
CAS Number:
Molecular Weight:
211.19
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Product Name
Stattic, ≥98% (HPLC), powder
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >20 mg/mL
SMILES string
[O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1
InChI
1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
InChI key
ZRRGOUHITGRLBA-UHFFFAOYSA-N
Related Categories
Application
Stattic has been used to inhibit signal transducer and activator of transcription 3 (STAT3) activity in various cell lines and culture.
Stattic was used to study Stat3-mediated cell signaling in human lung carcinoma cells.5
Biochem/physiol Actions
Stattic (Stat3 three inhibitory compound) alters the SH2 domain of Stat3 and indirectly inhibits with phosphopeptide binding. It is readily transported across the cell membrane compared to other phosphopeptides.2 Stattic induces increased formation of ROS and negatively affects the cardiomyocyte mitochondrial function,3 and sensitizes nasopharyngeal carcinoma cells to chemoradiotherapy.4
Stattic is an irreversible STAT3 activation inhibitor.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Yunbao Pan et al.
PloS one, 8(1), e54565-e54565 (2013-02-06)
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus-associated malignancy most common in East Asia, Africa and Alaska. Radiotherapy and cisplatin-based chemotherapy are the main treatment options. Unfortunately, disease response to concurrent chemoradiotherapy varies among patients with NPC, and many cases are
Karen Kwofie et al.
Respiratory research, 16, 14-14 (2015-04-08)
Regulation of human airway smooth muscle cells (HASMC) by cytokines contributes to chemotactic factor levels and thus to inflammatory cell accumulation in lung diseases. Cytokines such as the gp130 family member Oncostatin M (OSM) can act synergistically with Th2 cytokines
Jochen Schust et al.
Chemistry & biology, 13(11), 1235-1242 (2006-11-23)
Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that transmit signals from the cell membrane to the nucleus. One family member, STAT3, is constitutively activated by aberrant upstream tyrosine kinase activities in a
Proatherogenic stimuli induce HuR in atherosclerosis through MAPK/ErK pathway
Cheng M, et al.
American Journal of Translational Research, 11(4), 2317-2317 (2019)
Nikolaos Sismanopoulos et al.
PloS one, 7(3), e33271-e33271 (2012-03-14)
Interleukin 9 (IL-9) has been implicated in mast cell-related inflammatory diseases, such as asthma, where vascular endothelial growth factor (VEGF) is involved. Here we report that IL-9 (10-20 ng/ml) induces gene expression and secretion of VEGF from human LAD2. IL-9
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