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Merck
CN

S8031

Sigma-Aldrich

[pGlu5, D-Trp7,9,10]-Substance P Fragment 5-11

≥90% (HPLC)

Synonym(s):

pGlu-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2

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About This Item

Empirical Formula (Hill Notation):
C57H64N12O9S
CAS Number:
143675-79-0
Molecular Weight:
1093.26
MDL number:
MFCD00214674
UNSPSC Code:
12352209
PubChem Substance ID:
329824594
NACRES:
NA.26

Key Documents

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Product Name

[pGlu5, D-Trp7,9,10]-Substance P Fragment 5-11, ≥90% (HPLC)

Assay

≥90% (HPLC)

storage temp.

−20°C

SMILES string

CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](Cc6c[nH]c7ccccc67)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]8CCC(=O)N8)C(N)=O

InChI

1S/C57H64N12O9S/c1-79-24-23-42(51(59)72)64-55(76)46(26-33-29-60-39-16-8-5-13-36(33)39)69-57(78)48(28-35-31-62-41-18-10-7-15-38(35)41)68-54(75)45(25-32-11-3-2-4-12-32)66-56(77)47(27-34-30-61-40-17-9-6-14-37(34)40)67-53(74)44(19-21-49(58)70)65-52(73)43-20-22-50(71)63-43/h2-18,29-31,42-48,60-62H,19-28H2,1H3,(H2,58,70)(H2,59,72)(H,63,71)(H,64,76)(H,65,73)(H,66,77)(H,67,74)(H,68,75)(H,69,78)/t42-,43-,44-,45-,46+,47+,48+/m0/s1

InChI key

WSYRBHQWMXTCHQ-SFIKJRKMSA-N

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
086H12861
043H11231
086H1286
045H00161

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H Mukai et al.
The Journal of biological chemistry, 267(23), 16237-16243 (1992-08-15)
A substance P (SP) analog, [D-Pro4,D-Trp7,9,10] SP4-11, is known to inhibit the actions of various structurally unrelated messenger molecules as well as SP. Our studies on the effects of this peptide on the regulation of purified G proteins by receptor
Baomei Wang et al.
Cell reports, 26(6), 1614-1626 (2019-02-07)
β2-integrins promote neutrophil recruitment to infected tissues and are crucial for host defense. Neutrophil recruitment is defective in leukocyte adhesion deficiency type-1 (LAD1), a condition caused by mutations in the CD18 (β2-integrin) gene. Using a model of Citrobacter rodentium (CR)-induced

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