S8627
Sulfacetamide
≥98.0%
Synonym(s):
N-(4-Aminobenzenesulfonyl)acetamide, N-(4-Aminophenylsulfonyl)acetamide, N1-Acetylsulfanilamide
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About This Item
Empirical Formula (Hill Notation):
C8H10N2O3S
CAS Number:
Molecular Weight:
214.24
UNSPSC Code:
51283901
NACRES:
NA.85
PubChem Substance ID:
EC Number:
205-640-6
Beilstein/REAXYS Number:
981718
MDL number:
assay
≥98.0%
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycoplasma
mode of action
DNA synthesis | interferes
SMILES string
CC(=O)NS(=O)(=O)c1ccc(N)cc1
InChI
1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
InChI key
SKIVFJLNDNKQPD-UHFFFAOYSA-N
General description
Chemical structure: sulfonamide
Application
Sulfacetamide is used to study the treatment of acne and seborrheic dermatitis. It is used to study neonatal chlamydial conjunctivitis and meningococcal conjunctivitis.
Biochem/physiol Actions
Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
Packaging
100G,500G
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids
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signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 2
ppe
Eyeshields, Gloves, type N95 (US)
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SODIUM SULFACETAMIDE FOR SEBORRHEIC DERMATITIS
STEPHEN T. WHELAN
American Journal of Diseases of Children, 71, 724-724 (1955)
E Kremer et al.
Journal of inorganic biochemistry, 100(7), 1167-1175 (2006-04-06)
The synthesis, characterization and comparative biological study of a series of antibacterial copper complexes with heterocyclic sulfonamides were reported. Two kinds of complexes were obtained with the stoichiometries [Cu(L)2] . H2O and [Cu(L)2(H2O)4] . nH2O. They were characterized by infrared
Fatmah A M Al-Omary et al.
Bioorganic & medicinal chemistry, 18(8), 2849-2863 (2010-03-31)
A new series of 2,6-substituted-quinazolin-4-ones was designed, synthesized, and evaluated for their in vitro DHFR inhibition, antimicrobial, and antitumor activities. Compounds 22, 33-37, 39-43, and 45 proved to be active DHFR inhibitors with IC(50) range of 0.4-1.0microM. Compound 18 showed
Global Trade Item Number
| SKU | GTIN |
|---|---|
| S8627-500G | 04061833624531 |
| S8627-100G | 04061836960964 |