S8647
Sulfacetamide sodium salt monohydrate
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About This Item
Empirical Formula (Hill Notation):
C8H9N2NaO3S · H2O
CAS Number:
Molecular Weight:
254.24
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
MDL number:
form
powder
color
white to off-white
solubility
H2O: soluble 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycoplasma
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
NC1=CC=C(S(N([Na])C(C)=O)(=O)=O)C=C1.O
InChI
1S/C8H10N2O3S.Na.H2O/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8;;/h2-5H,9H2,1H3,(H,10,11);;1H2/q;+1;/p-1
InChI key
IHCDKJZZFOUARO-UHFFFAOYSA-M
General description
Chemical structure: sulfonamide
Biochem/physiol Actions
Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
Packaging
100G
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Margareta Ungureanu et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 110(2), 456-459 (2007-09-07)
In the present study we emphasized the antituberculosis action of new sulphacetamide derivatives. In order o extend the research for obtaining antituberculosis substances, we decided to study the influence of the introducing of the thiourea and sulphamide groups in the
Ilknur Akyol-Salman et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 28(1), 49-52 (2011-07-15)
This study aimed to compare the efficacy of topical N-acetyl-cysteine (NAC) with a topical steroid-antibiotic combination, betamethasone-sulfacetamide sodium therapy in patients with meibomian gland dysfunction (MGD). Twenty patients with MGD were prospectively randomized and assigned into 2 groups. The patients
M Gooderham
Skin therapy letter, 14(2), 1-3 (2009-03-31)
Many options exist for the treatment of rosacea, including topical and systemic therapies, laser and light-based therapies, and surgical procedures. A classification system for rosacea identifies 4 subtypes (i.e., erythematotelangiectatic, papulopustular, phymatous, and ocular), which may help guide therapeutic decision-making.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| S8647-100G | 04061836960971 |