Name: SKF-89976A
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₅NO₂ · HCl

CAS Number:

85375-15-1

Molecular Weight:

371.90

MDL number:

MFCD01321071

UNSPSC Code:

12352200

PubChem Substance ID:

24278796

NACRES:

NA.77

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Assay

>98% (HPLC)

form

solid

color

white

solubility

DMSO: soluble 20 mg/mL
H₂O: insoluble

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

Cl[H].OC(=O)C1CCCN(CC\C=C(/c2ccccc2)c3ccccc3)C1

InChI

1S/C22H25NO2.ClH/c24-22(25)20-13-7-15-23(17-20)16-8-14-21(18-9-3-1-4-10-18)19-11-5-2-6-12-19;/h1-6,9-12,14,20H,7-8,13,15-17H2,(H,24,25);1H

InChI key

SNGGBKYQZVAQKA-UHFFFAOYSA-N

Gene Information

human ... SLC6A1(6529), SLC6A11(6538), SLC6A12(6539)
rat ... Slc6a1(79212), Slc6a12(50676)

Application

SKF-89976A was used to study the role of adenosine receptors in uptake of GABA transport.^4,5

Biochem/physiol Actions

GABA transporter type 1 (GAT-1) inhibitor that crosses the blood brain barrier.

SKF-89976A contains a cyclic amino acid with lipophilic moiety that enables the compound to cross the blood-brain barrier.^1,2 It decreases the excitotoxic swelling of chick retina cells by blocking the glutamate-induced GABA release.³

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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