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Merck
CN

S9321

Saikosaponin D from Bupleurum falcatnum

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About This Item

Empirical Formula (Hill Notation):
C42H68O13
Molecular Weight:
780.98
NACRES:
NA.25
PubChem Substance ID:
329824621
UNSPSC Code:
12352200
MDL number:
MFCD09028095

Key Documents

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InChI key

KYWSCMDFVARMPN-LCSVLAELSA-N

SMILES string

CC1(C)CC[C@]23[C@H](O)C[C@@]4(C)[C@]5(C)CC[C@@]6([H])[C@@](CO)(C)[C@@H](O[C@]7([H])O[C@H](C)[C@H](O)[C@H](O[C@]8([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@H]7O)CC[C@]6(C)[C@@]5([H])C=C[C@]4(OC3)[C@]2([H])C1

InChI

1S/C42H68O13/c1-21-28(46)33(55-34-31(49)30(48)29(47)22(18-43)53-34)32(50)35(52-21)54-27-10-11-37(4)23(38(27,5)19-44)8-12-39(6)24(37)9-13-42-25-16-36(2,3)14-15-41(25,20-51-42)26(45)17-40(39,42)7/h9,13,21-35,43-50H,8,10-12,14-20H2,1-7H3/t21-,22-,23-,24-,25-,26-,27+,28+,29-,30+,31-,32-,33+,34+,35+,37+,38+,39-,40+,41-,42+/m1/s1

assay

≥95% (HPLC)

form

powder

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

Biochem/physiol Actions

Saikosaponin D inhibits cell growth of human cancer cells by inducing apoptosis and blocking cell cycle progression in the G1 phase. Saikosaponin D was found to stimulate corticotropin-releasing factor (CRF) gene expression and CRF release.

Application

Saikosaponins such as Saikosaponin D are used to help analyse and resolve the activities of herbal medicines such as Sho-saiko-to.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品
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Certificates of Analysis (COA)

Lot/Batch Number
MKCD5840
MKCD5841
MKCC6132
MKBR0890V
041M1698V

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Sho-saiko-to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma.
Shimizu I.
Journal of Gastroenterology and Hepatology, 15, Suppl D84-Suppl D90 (2000)
I Sakaida et al.
Journal of hepatology, 28(2), 298-306 (1998-03-26)
A herbal medicine, Sho-saiko-to (TJ-9), has recently been orally administered to patients with chronic liver disease in Japan and has been reported to inhibit the development of hepatocellular carcinoma. The aim of this study was to investigate whether TJ-9 has
K Kayano et al.
Journal of hepatology, 29(4), 642-649 (1998-11-21)
It is of extreme importance to prevent liver fibrosis and subsequent progression to liver cirrhosis. The aim of our study was to elucidate in vitro whether Sho-saiko-to exerted inhibitory effects on hepatic stellate cells. Hepatic stellate cells were isolated from

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