Key Documents

View All Documentation

S9321

Saikosaponin D from Bupleurum falcatnum

Name: Saikosaponin D from <I>Bupleurum falcatnum</I>
Brand: SIGMA

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₄₂H₆₈O₁₃

Molecular Weight:

780.98

NACRES:

NA.25

PubChem Substance ID:

329824621

UNSPSC Code:

12352200

MDL number:

MFCD09028095

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

assay

≥95% (HPLC)

form

powder

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

CC1(C)CC[C@]23[C@H](O)C[C@@]4(C)[C@]5(C)CC[C@@]6([H])[C@@](CO)(C)[C@@H](O[C@]7([H])O[C@H](C)[C@H](O)[C@H](O[C@]8([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@H]7O)CC[C@]6(C)[C@@]5([H])C=C[C@]4(OC3)[C@]2([H])C1

InChI

1S/C42H68O13/c1-21-28(46)33(55-34-31(49)30(48)29(47)22(18-43)53-34)32(50)35(52-21)54-27-10-11-37(4)23(38(27,5)19-44)8-12-39(6)24(37)9-13-42-25-16-36(2,3)14-15-41(25,20-51-42)26(45)17-40(39,42)7/h9,13,21-35,43-50H,8,10-12,14-20H2,1-7H3/t21-,22-,23-,24-,25-,26-,27+,28+,29-,30+,31-,32-,33+,34+,35+,37+,38+,39-,40+,41-,42+/m1/s1

InChI key

KYWSCMDFVARMPN-LCSVLAELSA-N

Description

Application

Saikosaponins such as Saikosaponin D are used to help analyse and resolve the activities of herbal medicines such as Sho-saiko-to.

Biochem/physiol Actions

Saikosaponin D inhibits cell growth of human cancer cells by inducing apoptosis and blocking cell cycle progression in the G1 phase. Saikosaponin D was found to stimulate corticotropin-releasing factor (CRF) gene expression and CRF release.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Herbal medicine Sho-saiko-to (TJ-9) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet.

I Sakaida et al.

Journal of hepatology, 28(2), 298-306 (1998-03-26)

A herbal medicine, Sho-saiko-to (TJ-9), has recently been orally administered to patients with chronic liver disease in Japan and has been reported to inhibit the development of hepatocellular carcinoma. The aim of this study was to investigate whether TJ-9 has

Sho-saiko-to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma.

Shimizu I.

Journal of Gastroenterology and Hepatology, 15, Suppl D84-Suppl D90 (2000)

Inhibitory effects of the herbal medicine Sho-saiko-to (TJ-9) on cell proliferation and procollagen gene expressions in cultured rat hepatic stellate cells.

K Kayano et al.

Journal of hepatology, 29(4), 642-649 (1998-11-21)

It is of extreme importance to prevent liver fibrosis and subsequent progression to liver cirrhosis. The aim of our study was to elucidate in vitro whether Sho-saiko-to exerted inhibitory effects on hepatic stellate cells. Hepatic stellate cells were isolated from

Global Trade Item Number

SKU	GTIN
S9321-1MG	04061826168073
S9321-5MG	04061833051108