S9511
Superoxide Dismutase from canine erythrocytes
lyophilized powder, 2,000-6,000 units/mg protein
Synonym(s):
SOD, Superoxide: superoxide oxidoreductase
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About This Item
CAS Number:
UNSPSC Code:
12352204
EC Number:
232-943-0
MDL number:
form
lyophilized powder
specific activity
2,000-6,000 units/mg protein
mol wt
~31,200 (two identical subunits)
composition
Protein, ≥90% biuret
UniProt accession no.
storage temp.
−20°C
Gene Information
dog ... SOD1(403559)
Biochem/physiol Actions
Catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. Plays a critical role in the defense of cells against the toxic effects of oxygen radicals. Competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby promoting the activity of NO.1 SOD has also been shown to suppress apoptosis in cultured rat ovarian follicles, neural cell lines and transgenic mice.2,3
Physical form
Lyophilized powder containing potassium phosphate buffer salts
Analysis Note
For assay method, see McCord, J.M. and Fridovich,I., J. Biol. Chem., 244, 6049 (1969).
Other Notes
One unit will inhibit reduction of cytochrome c by 50% in a coupled system with xanthine oxidase at pH 7.8 at 25 °C in a 3.0 mL reaction volume. Xanthine oxidase concentration should produce an initial ΔA550 of 0.025 ± 0.005 per min.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Bovine erythrocyte superoxide dismutase. Complete amino acid sequence.
H M Steinman et al.
The Journal of biological chemistry, 249(22), 7326-7338 (1974-11-25)
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