SAB1300104
Anti-CAMK2δ-like (C-term) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Anti-CAMK2G, Anti-CaM-kinase II γ chain, Anti-Calcium/calmodulin-dependent protein kinase type II γ chain, CaM kinase II γ subunit, CaMK-II γ subunit
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IHC, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human, mouse
technique(s)
immunohistochemistry: 1:50-1:100, indirect ELISA: 1:1000, western blot: 1:100-1:500
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CAMK2(818)
General description
Ca2+/calmodulin-dependent kinase II γ (CaMKIIγ) gene is mapped to human chromosome 10q22.2. The encoded protein is a multifunctional serine/threonine kinase and is specific to various substrates. CaMKII contains four isoforms: CaMKIIα/β/γ/δ. CaMKII is ubiquitously expressed in humans. The protein consists of an N-terminal catalytic domain, a regulatory domain, and a C-terminal association domain.
CaM-kinase II (CAMK2) is a prominent Ser/Thr protein kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Likely autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.
The previously assigned protein identifier O15378 has been merged into Q13555. Full details can be found on the UniProt database.
The previously assigned protein identifier O15378 has been merged into Q13555. Full details can be found on the UniProt database.
Immunogen
CAMK2 (NP_751911, 314-348)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-term region of human CAMK2 delta-like.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-term region of human CAMK2 delta-like.
Biochem/physiol Actions
CaMKIIγ (Ca2+/calmodulin-dependent kinase II γ) is mostly expressed in tumor-initiating cells. CaMKIIγ regulates the progression of cancer cells in leukemia, lung cancer, and liver cancer. CaMKIIγ participates in the β-catenin, Stat3 (signal transducer and activator of transcription 3), and NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signal pathways..
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Thomas J Hund et al.
Trends in cardiovascular medicine, 25(5), 392-397 (2015-01-13)
Protein phosphorylation is a central mechanism in vertebrates for the regulation of signaling. With regard to the cardiovascular system, phosphorylation of myocyte targets is critical for the regulation of excitation contraction coupling, metabolism, intracellular calcium regulation, mitochondrial activity, transcriptional regulation
Lam C Tsoi et al.
Nature communications, 6, 7001-7001 (2015-05-06)
Psoriasis is a chronic autoimmune disease with complex genetic architecture. Previous genome-wide association studies (GWAS) and a recent meta-analysis using Immunochip data have uncovered 36 susceptibility loci. Here, we extend our previous meta-analysis of European ancestry by refined genotype calling
Shoujie Chai et al.
Oncotarget, 6(18), 16069-16083 (2015-05-13)
Highly tumorigenic stem-like cells, considered tumor-initiating cells (TICs), are the main cause of lung cancer initiation, relapse, and drug resistance. In this study, we identified that Ca2+/calmodulin-dependent protein kinase IIγ (CaMKIIγ) was aberrantly expressed in highly tumorigenic stem-like lung cancer
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