SAB1300243
Anti-drh-1 (N-term) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Anti-Dicer related helicase protein 1, Anti-Dicer-related helicase, Anti-Drh-1
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
Caenorhabditis elegans
technique(s)
indirect ELISA: 1:1000
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
Caenorhabditis elegans ... Drh-1(177425)
General description
Human Drh-1 protein possesses an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. DICER, also known as helicase-MOI, is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. The 21-nucleotide small temporal RNA (stRNA) let7 regulates developmental timing in C. elegans and probably in other bilateral animals. In Drosophila, a developmentally regulated precursor RNA is cleaved by an RNA interference-like mechanism to produce mature let7 stRNA. Targeted disruption in cultured human cells of the mRNA encoding the enzyme Drh-1, which acts in the RNA interference pathway, leads to accumulation of the LET7 precursor. Thus, the RNA interference and stRNA pathways intersect. Both pathways require the RNA processing enzyme Drh-1 to produce the active small RNA component that represses gene expression.
Immunogen
DRH (NP_501018, 12-46)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of C. elegans Drh-1.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of C. elegans Drh-1.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Claudia D Consalvo et al.
eLife, 13 (2024-05-15)
Invertebrates use the endoribonuclease Dicer to cleave viral dsRNA during antiviral defense, while vertebrates use RIG-I-like Receptors (RLRs), which bind viral dsRNA to trigger an interferon response. While some invertebrate Dicers act alone during antiviral defense, Caenorhabditis elegans Dicer acts
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