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Merck
CN

SAB1300728

Anti-Phospho-ANTXR1-pY382 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-ANTXR1, Anti-ATR, Anti-Anthrax toxin receptor 1 [Precursor], Anti-TEM8, Anti-Tumor endothelial marker 8

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About This Item

NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
DB, ELISA (i)
Citations:
-

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

dot blot: suitable, indirect ELISA: 1:1000

NCBI accession no.

NP_115584

UniProt accession no.

Q9H6X2

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr382)

Gene Information

human ... ANTXR1(84168)

General description

ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.

Immunogen

ANTXR1 (NP_115584, 363-396)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y382 of human ANTXR1.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
010M0532

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