SAB1300919
Anti-PHLPP2 (N-term) antibody produced in rabbit
saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution
Synonym(s):
Anti-KIAA0931, Anti-PH domain leucine-rich repeat protein phosphatase-like, Anti-PHLPP-like, Anti-PHLPP2, Anti-PHLPPL
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IHC
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
saturated ammonium sulfate (SAS) precipitated
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry: 1:50-1:100, indirect ELISA: 1:1000
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PHLPP2(23035)
General description
The PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2) gene with 18 exons, is mapped to human chromosome 16q22.2. The encoded protein is a isoform of PHLPP family and is composed of 1323 amino acids. PHLPP2 is characterized with a pleckstrin homology domain (PH domain), leucine-rich repeats, a protein phosphatase 2C (PP2C) domain and a PDZ-binding motif.
Immunogen
PHLPP2 (NP_055835, 9-42)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human PHLPP2.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human PHLPP2.
Application
Anti-PHLPP2 (N-term) antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2) is a tumor suppressor. It plays a vital role in cell survival by inactivating Akt, inhibiting cell-cycle progression and stimulating apoptosis. Expression of PHLPP protein is decreased in hypopharyngeal squamous cell carcinomas (HSCCs). Thus, this protein can be used as a marker to determine the poor prognosis in HSCCs patients.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Haiyan Xing et al.
Frontiers in pharmacology, 11, 1065-1065 (2020-08-09)
Hyperoside, isolated from Drosera rotundifolia L., seeds of Cuscuta chinensis Lam., or Hypericum perforatum L., originally showed to possess an antifungal and antibacterial activity, while recently showed the protective effects against oxidative stress-induced liver injury. This study investigated such a
Fatima Rizvi et al.
Redox biology, 6, 587-598 (2015-10-30)
Recent advances indicate a possible role of phytochemicals as modulatory factors in signaling pathways. We have previously demonstrated PHLPP2-mediated suppression of Nrf2 responses during oxidant attack. The present study was designed to explore Nrf2-potentiating mechanism of morin, a flavonol, via
Aberrant expression of PHLPP1 and PHLPP2 correlates with poor prognosis in patients with hypopharyngeal squamous cell carcinoma.
Zhou J
PLoS ONE, 10 (2015)
PHLPP2 down regulation influences nuclear Nrf2 stability via Akt-1/Gsk3?/Fyn kinase axis in acetaminophen induced oxidative renal toxicity: Protection accorded by morin.
Mathur A
Food And Chemical Toxicology, 89, 19-31 (2016)
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