SAB1304932
ANTI-NUP88 (C-TERM) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
NUP88, Nuclear pore complex protein Nup88
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
83542 Da
species reactivity
human
technique(s)
western blot: 1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
General description
NUP88 (Nucleoporin 88kDa) is an 88kDa non-FG nucleoporin. It acts as a component of a novel nuclear pore complex (NPC). It consists of a C-terminal coiled-coil domain and an interaction domain. It is localized in the cytoplasmic surface of nuclear pore complexes (NPCs). NUP88 consists of two domains, N-terminal and C-terminal domains and its N-terminal and C-terminal domains have been predicted to form β-propeller and a coiled-coil domain.
Application
ANTI-NUP88 (C-TERM) antibody produced in rabbit is suitable for western blot analysis at a dilution of 1:250-1:500.
Biochem/physiol Actions
NUP88 (Nucleoporin 88kDa) participates in trafficking between the nucleus and cytoplasm. Its N-terminal β-propeller domain interacts with the FG (phenylalanine-glycine) repeat domain of nucleoporin CAN/Nup214. Further, it binds directly to CRM-1/exportin-1, the receptor for export of most proteins from the nucleus. Nup88 also possesses the ability to bind to the other FG nucleoporins Nup358 and Nup98. Overexpression of NUP88 has been observed in several types of malignancies such as colorectal cancer (CRC) and breast cancer cells.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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M Fornerod et al.
The EMBO journal, 16(4), 807-816 (1997-02-17)
The oncogenic nucleoporin CAN/Nup214 is essential in vertebrate cells. Its depletion results in defective nuclear protein import, inhibition of messenger RNA export and cell cycle arrest. We recently found that CAN associates with proteins of 88 and 112 kDa, which
Chieko Hashizume et al.
Molecular cancer, 9, 119-119 (2010-05-26)
Nuclear pore complexes are massive multiprotein channels responsible for traffic between the nucleus and cytoplasm, and are composed of approximately 30 proteins, termed nucleoporins (Nup). Our recent studies indicated that the nucleoporins Rae1 and Tpr play critical roles in maintaining
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