SAB1305653
ANTI-BCL-2 (BH3 DOMAIN SPECIFIC) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Apoptosis regulator Bcl-2, BCL2
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
polyclonal
Species reactivity:
human
Application:
IF, IHC, WB
Citations:
3
biological source
rabbit
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
26266 Da
species reactivity
human
technique(s)
immunofluorescence: 1:10-1:50, immunohistochemistry: 1:10-1:50, western blot: 1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BCL2(596)
General description
B-cell lymphoma 2 (BCL-2) is an anti-apoptotic and target gene of nuclear factor-κB (NF-κB). The protein is expressed in the nuclear envelope, mitochondria and endoplasmic reticulum. The gene encoding BCL-2 is localized on human chromosome 18q21.
Biochem/physiol Actions
B-cell lymphoma 2 (BCL-2) inhibits apoptosis in cells and has been shown to be upregulated in adenomas.
Physical form
Supplied in PBS with 0.09% (W/V) sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression.
Portier BP and Taglialatela G
The Journal of Biological Chemistry, 281(52), 40493-40502 (2006)
Maartje van der Heijden et al.
Nature communications, 7, 10916-10916 (2016-03-10)
Intestinal tumour formation is generally thought to occur following mutational events in the stem cell pool. However, active NF-κB signalling additionally facilitates malignant transformation of differentiated cells. We hypothesized that genes shared between NF-κB and intestinal stem cell (ISCs) signatures
Peng Lin et al.
Molecular medicine reports, 12(5), 7699-7704 (2015-10-16)
Increasing evidence has indicated that the generation of reactive oxygen species (ROS) contributes to H2O2‑induced nerve injury. This may result in oxidative stress that leads to cell damage or death. Dietary or pharmaceutical augmentation of the endogenous antioxidant defense capacity
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB1305653-400UL | 04061835616374 |