SAB1306582
Anti-Ubiquitin antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Polyubiquitin-C, UBC, Ubiquitin
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
77039 Da
species reactivity
human
technique(s)
immunofluorescence: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... UBC(7316)
General description
Ubiquitin, also known as ubiquitin C (UBC), is a globular protein, encoded by the gene mapped to human chromosome 12q24.31. The encoded protein consists of 76 amino acids.
Immunogen
a synthetic peptide between 36-66 amino acids of human Ubiquitin, which is in the Ubiquitin-like 1 domain
Application
Anti-ubiquitin antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Ubiquitin plays a major role in protein degradation. Ubiquitin-mediated degradation of regulatory proteins has been implicated in the regulation of various processes, such as cell-cycle progression, signal transduction, transcriptional regulation, receptor down-regulation and endocytosis. Aberrations in the ubiquitin-mediated pathways contribute to malignant transformation.
Physical form
Supplied in PBS with 0.09% (W/V) sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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The VHL short variant involves in protein quality control
Liu Y, et al.
Gene, 589, 63-71 (2016)
Ubiquitin recognition by the proteasome
Saeki Y, et al.
Journal of Biochemistry, 161, 113-124 (2017)
Localization of the human UBC polyubiquitin gene to chromosome band 12q24.3.
Board PG, et al.
Genomics, 12, 639-642 (1992)
Jia-Hua Qu et al.
eLife, 12 (2024-01-22)
Our prior study (Tarasov et al., 2022) discovered that numerous adaptive mechanisms emerge in response to cardiac-specific overexpression of adenylyl cyclase type 8 (TGAC8) which included overexpression of a large number of proteins. Here, we conducted an unbiased phosphoproteomics analysis
A Hershko et al.
Annual review of biochemistry, 67, 425-479 (1998-10-06)
The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small protein. Ubiquitin-mediated degradation of regulatory proteins
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