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Merck
CN

SAB1402496

Monoclonal Anti-PQBP1, (C-terminal) antibody produced in mouse

clone 1A11, purified immunoglobulin, buffered aqueous solution

Synonym(s):

MRX55, MRXS3, MRXS8, NPW38, RENS1, SHS

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1A11, monoclonal

form

buffered aqueous solution

mol wt

antigen ~35.13 kDa

species reactivity

human

technique(s)

indirect ELISA: suitable, western blot: 1-5 μg/mL

isotype

IgG2aκ

NCBI accession no.

NM_005710

UniProt accession no.

O60828

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PQBP1(10084)

General description

PQBP1 is a nuclear polyglutamine-binding protein that contains a WW domain (Waragai et al., 1999 [PubMed 10332029]).[supplied by OMIM

Immunogen

PQBP1 (NP_005701, 184 a.a. ~ 265 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
LAPYPKSKKAVSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRTKQQD

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
I9201-1A11
08081-1A11

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Sunnie M Yoh et al.
Molecular cell, 82(15), 2871-2884 (2022-07-10)
We have previously described polyglutamine-binding protein 1 (PQBP1) as an adapter required for the cyclic GMP-AMP synthase (cGAS)-mediated innate response to the human immunodeficiency virus 1 (HIV-1) and other lentiviruses. Cytoplasmic HIV-1 DNA is a transient and low-abundance pathogen-associated molecular

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