SAB1406719
Anti-RAB11A antibody produced in mouse
purified immunoglobulin, buffered aqueous solution
Synonym(s):
MGC1490, YL8
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
5
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~24.4 kDa
species reactivity
human
technique(s)
western blot: 1 μg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RAB11A(8766)
General description
Ras-related protein Rab-11A (RAB11A), member RAS oncogene family, is a GTP binding protein. RAB11A gene is located on human chromosome 15q21.3. RAB11A is expressed abundantly in tissues with high secretion.
Immunogen
RAB11A (NP_004654.1, 1 a.a. ~ 216 a.a) full-length human protein.
Sequence
MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI
Sequence
MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI
Biochem/physiol Actions
Ras-related protein Rab-11A (RAB11A), member RAS oncogene family, is involved in vesicle trafficking during recycling of endosomes. Overexpression of RAB11A leads to an increased collective cell invasion in colorectal carcinoma.RAB11A and its binding partners plays a crucial role in recycling of human β1-adrenergic receptor.
Physical form
Solution in phosphate buffered saline, pH 7.4
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis
Gebhardt C, et al.
The American Journal of Pathology, 167(1), 243-253 (2005)
Rab11a and its binding partners regulate the recycling of the ss1-adrenergic receptor
Gardner LA, et al.
Cellular Signalling, 23(1), 46-57 (2011)
Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma
Chung YC, et al.
European Journal of Clinical Investigation, 46(12), 1002-1011 (2016)
Molecular mechanism of constitutively active Rab11A was revealed by crystal structure of Rab11A S20V
Choi JY, et al.
Febs Letters, 590(6), 819-827 (2016)
Kazumori Kawakami et al.
Oncology reports, 16(3), 521-531 (2006-07-26)
Large-scale gene expression profiling is an effective strategy for understanding the progression of bladder cancer (BC). The aim of this study was to identify genes that are expressed differently in the course of BC progression and to establish new biomarkers
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