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Merck
CN

SAB1407360

Sigma-Aldrich

Anti-KCNMB4 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~23.9 kDa

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

NM_014505

UniProt accession no.

Q86W47

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KCNMB4(27345)

General description

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. (provided by RefSeq)
Potassium calcium activated channel subfamily M regulatory β subunit 4 (KCNMB4) is mapped to human chromosome 12q14.1-15. The encoded protein is a member of the potassium channel β subunit family. KCNMB4 contains two transmembrane segments (TM1 and TM2), intracellular N and C terminal and a large extracellular loop. It is mainly expressed in the brain, neuronal tissue, kidney and bladder smooth muscle.

Immunogen

KCNMB4 (NP_055320.4, 1 a.a. ~ 210 a.a) full-length human protein.

Sequence
MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS

Biochem/physiol Actions

Potassium calcium activated channel subfamily M regulatory α subunit 4 (KCNMB4) plays a vital role in increasing Ca2+ sensitivity. It reduces the voltage dependence of the conductance-voltage relationship as well as the slope of the gating charge-voltage curve.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
09064

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hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large?conductance calcium?activated potassium channel β subunit family
Behrens R, et al.
Febs Letters, 474(1), 99-106 (2000)
Pharmacological consequences of the coexpression of BK channel α and auxiliary β subunits
Torres YP, et al.
Frontiers in Physiology, 5, 383-383 (2014)

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