SAB1412040
ANTI-ISL1 antibody produced in mouse
clone 8A3, purified immunoglobulin, buffered aqueous solution
Synonym(s):
ISL1, Isl-1
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
8A3, monoclonal
Application:
ELISA (i), IF, WB
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
8A3, monoclonal
form
buffered aqueous solution
mol wt
antigen 36.41 kDa
species reactivity
human
technique(s)
indirect ELISA: suitable, indirect immunofluorescence: suitable, western blot: 1-5 μg/mL
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ISL1(3670)
General description
Insulin gene enhancer binding protein-1 (ISL-1) gene spanning 220kb of genomic DNA, is mapped to human chromosome 5q11.1. The gene codes for a member of LIM zinc-binding/homeobox-domain transcription factor and is predominantly expressed in hindbrain, forebrain, ventral neural tube, dorsal root ganglia (DRG) and trigeminal ganglia.
Immunogen
ISL1 (NP_002193, 63 a.a. ~ 159 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
YCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEP
Sequence
YCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEP
Biochem/physiol Actions
Insulin gene enhancer binding protein-1 (ISL-1) is a transcription factor which plays a vital role in the development of the heart, motor neurons and pancreas. It also stimulates adult pancreatic β-cells proliferation. ISL1 might also be involved in the regulation of insulin expression. Elevated expression of the gene has been observed in patients with gastric cancer. Thus, the protein can be used as a potential biomarker and therapeutic target for gastric cancer. Mutation in the gene is associated with the increased risk of susceptibility to human congenital heart disease (CHD).
Physical form
Solution in phosphate buffered saline, pH 7.4
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Storage Class
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Genome-wide association study and meta-analysis identify ISL1 as genome-wide significant susceptibility gene for bladder exstrophy
Draaken M
PLoS Genetics, 11 (2015)
An abnormally high expression of ISL-1 represents a potential prognostic factor in gastric cancer.
Guo C
Human Pathology, 46, 1282-1289 (2015)
Common variation in ISL1 confers genetic susceptibility for human congenital heart disease.
Stevens KN
PLoS ONE, 5 (2010)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB1412040-100UG | 04061829669935 |