SAB2500130
Anti-ATF4 antibody produced in goat
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Activating transcription factor 4, Anti-CREB2, Anti-TAXREB67, Anti-TXREB
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About This Item
UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), WB
Citations:
5
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ATF4(468)
General description
Activating transcription factor 4 (ATF4) is a transcription factor and the gene encoding it is localized on human chromosome 22q13.1.
Immunogen
Peptide with sequence C-EEVRKARGKKRVP from the C Terminus of the protein sequence according to NP_001666.
Biochem/physiol Actions
Activating transcription factor 4 (ATF4) acts as a master modulator of cellular adaptation to stress responses. It regulates the transcription of genes related to amino acid synthesis and import, redox balance and angiogenesis. The protein also has a role in the regulation of lipid metabolism. ATF4 is part of the unfolded protein response (UPR) pathway, which is activated in Alzheimer′s disease.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells.
Timosenko E
Cancer Research (2016)
Association of ATF4 Expression With Tissue Hypoxia and M2 Macrophage Infiltration in Infantile Hemangioma.
Xia HF
The Journal of Histochemistry and Cytochemistry (2017)
Homozygosity mapping in a family presenting with
schizophrenia, epilepsy and hearing impairment
schizophrenia, epilepsy and hearing impairment
Helen M Knight
European Journal of Human Genetics (2008)
Impact of activating transcription factor 4 signaling on lipogenesis in HepG2 cells.
Ren LP
Molecular Medicine Reports (2016)
Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions
Jimena Baleriola
Cell (2014)
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