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Merck
CN

SAB2500130

Sigma-Aldrich

Anti-ATF4 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Activating transcription factor 4, Anti-CREB2, Anti-TAXREB67, Anti-TXREB

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About This Item

MDL number:
MFCD01092263
UNSPSC Code:
12352203

Key Documents

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biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P18848

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ATF4(468)

General description

Activating transcription factor 4 (ATF4) is a transcription factor and the gene encoding it is localized on human chromosome 22q13.1.

Immunogen

Peptide with sequence C-EEVRKARGKKRVP from the C Terminus of the protein sequence according to NP_001666.

Biochem/physiol Actions

Activating transcription factor 4 (ATF4) acts as a master modulator of cellular adaptation to stress responses. It regulates the transcription of genes related to amino acid synthesis and import, redox balance and angiogenesis. The protein also has a role in the regulation of lipid metabolism. ATF4 is part of the unfolded protein response (UPR) pathway, which is activated in Alzheimer′s disease.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
5247S2C2
5247P1
5247C2

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Homozygosity mapping in a family presenting with
schizophrenia, epilepsy and hearing impairment
Helen M Knight
European Journal of Human Genetics (2008)
Impact of activating transcription factor 4 signaling on lipogenesis in HepG2 cells.
Ren LP
Molecular Medicine Reports (2016)
Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions
Jimena Baleriola
Cell (2014)
Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells.
Timosenko E
Cancer Research (2016)
Association of ATF4 Expression With Tissue Hypoxia and M2 Macrophage Infiltration in Infantile Hemangioma.
Xia HF
The Journal of Histochemistry and Cytochemistry (2017)

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