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Merck
CN

SAB2500237

Anti-CHRNA4 (AA 29-43) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-BFNC, Anti-Cholinergic receptor nicotinic α4, Anti-EBN

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), WB
Citations:
4

Key Documents

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biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human, canine, bovine, rat

technique(s)

indirect ELISA: suitable, western blot: suitable

UniProt accession no.

P43681

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CHRNA4(1137)

General description

CHRNA4 (cholinergic receptor nicotinic α4 subunit) encodes the α4 subunit of α4/β2-containing receptors. This gene is ~17 kb long and has six exons. CHRNA4 is located on human chromosome 20q13.2–13.3.

Immunogen

Peptide with sequence C-HVETRAHAEERLLKK from the internal region of the protein sequence according to NP_000735.1.

Biochem/physiol Actions

CHRNA4 (cholinergic receptor nicotinic α 4 subunit) plays an important role in ND (nicotine dependence). Mutations in CHRNA4 is linked with PIU (problematic internet use). In adult males, polymorphism in CHRNA4 is associated with depression and loneliness.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
8852P1

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The association between the nicotinic acetylcholine receptor ?4 subunit gene (CHRNA4) rs1044396 and Internet gaming disorder in Korean male adults.
Jeong JE, et al.
PLoS ONE, 12(12), e0188358-e0188358 (2017)
Association of common polymorphisms in the nicotinic acetylcholine receptor alpha4 subunit gene with an electrophysiological endophenotype in a large population-based sample.
Mobascher A, et al.
PLoS ONE, 11(4), e0152984-e0152984 (2016)
Ethnic-and gender-specific association of the nicotinic acetylcholine receptor α4 subunit gene (CHRNA4) with nicotine dependence.
Li M D, et al.
Human Molecular Genetics, 14(9), 1211-1219 (2005)
Association of CHRNA4 polymorphism with depression and loneliness in elderly males.
Tsai S J, et al.
Genes, Brain, and Behavior, 11(2), 230-234 (2012)

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