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Merck
CN

SAB2500273

Anti-CRHR1/CRF-R (AA 250-263) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CRF-R, Anti-CRF1, Anti-CRH-R1h, Anti-Corticotropin releasing hormone receptor 1

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC
Citations:
4

Key Documents

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biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry: suitable, indirect ELISA: suitable, indirect immunofluorescence: suitable

UniProt accession no.

P34998

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CRHR1(1394)

General description

Corticotropin releasing factor receptor 1 (CRHR1) belongs to the G-protein-coupled receptor superfamily of brain-gut neuropeptides. It is highly expressed in the amygdala, hippocampus and frontal cortex. The gene encoding CRHR1 consists of 13 exons and is localized on human chromosome 17q12-q22.

Immunogen

Peptide with sequence KLYYDNEKCWFGKR from the internal region of the protein sequence according to NP_004373.2.

Biochem/physiol Actions

Corticotropin releasing factor receptor 1 (CRHR1) helps to initiate signal transduction pathways that control various functions like stress, reproduction, immune response and obesity. It blocks the multiplication of endocrine-related cancer cell lines.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
7553G2
7553P1

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Association analysis of polymorphisms of the CRHR1 gene with infantile spasms
Guang Yang
Molecular Medicine Reports (2015)
Urocortinergic system in the testes of normal and cryptorchid dogs
Caterina Squillacioti
Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft, 207 (2016)
The activation of type 1 corticotropin releasing factor receptor (CRF-R1) inhibits proliferation and promotes differentiation of neuroblastoma cells in vitro via p27(Kip1) protein up-regulation and c-Myc mRNA down-regulation.
Pozzoli G
Molecular and Cellular Endocrinology (2015)
Family Economic Hardship, Corticotropin-Releasing Hormone Receptor Polymorphisms, and Depressive Symptoms in Rural African American Youths
Yi-fu Chen
The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine (2015)

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