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Merck
CN

SAB2500475

Anti-GOT2 (AA 295-306) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Aspartate aminotransferase 2, Anti-FLJ40994, Anti-Glutamic-oxaloacetic transaminase 2

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), WB
Citations:
3

Key Documents

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biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

technique(s)

indirect ELISA: suitable, western blot: suitable

UniProt accession no.

P00505

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GOT2(2806)

General description

The GOT2 (glutamic-oxaloacetic transaminase 2) gene is mapped to human chromosome 16q21 and the encoded protein is localized to mitochondria.

Immunogen

Peptide with sequence CKDADEAKRVES from the internal region of the protein sequence according to NP_002071.2.

Biochem/physiol Actions

GOT2 (glutamic-oxaloacetic transaminase 2) participates in malate–aspartate shuttle, which increases the rate of glycolysis via cytosolic NADH (nicotinamide adenine dinucleotide) transfer into mitochondria. This supports rapid growth in tumor cell. GOT2 catalyzes the transamination reaction involving oxaloacetate and L-glutamate to give rise to aspartate, also generating α-ketoglutarate in mitochondria. Aspartate, that is formed, serves as a precursor of N-acetylaspartate, a predominantly abundant free amino acid found in the brain.

Features and Benefits

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Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

低风险生物材料
常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
8295P1

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Association study of got2 genetic polymorphisms and schizophrenia.
Tsai S J, et al.
Psychiatric Genetics, 17(5), 314-314 (2007)
Silvia Sookoian et al.
World journal of gastroenterology, 21(3), 711-725 (2015-01-28)
For several decades, serum levels of alanine (ALT) and aspartate (AST) aminotransferases have been regarded as markers of liver injury, including a wide range of etiologies from viral hepatitis to fatty liver. The increasing worldwide prevalence of metabolic syndrome and
Hui Yang et al.
The EMBO journal, 34(8), 1110-1125 (2015-03-11)
The malate-aspartate shuttle is indispensable for the net transfer of cytosolic NADH into mitochondria to maintain a high rate of glycolysis and to support rapid tumor cell growth. The malate-aspartate shuttle is operated by two pairs of enzymes that localize

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