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Merck
CN

SAB2500530

Anti-IFT88/Polaris antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-D13S1056E, Anti-HGNC:20606, Anti-Polaris, Anti-TTC10, Anti-Tetratricopeptide repeat domain 10

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, IHC
Citations:
4

Key Documents

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biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human

technique(s)

ELISA: suitable, immunofluorescence: suitable, immunohistochemistry: suitable

UniProt accession no.

Q13099

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IFT88(8100)

General description

Intraflagellar transport 88 (IFT88) is a liver tumor suppressor gene. It consists of 824 amino acids and possesses tetratricopeptide repeats.

Immunogen

Peptide with sequence C-KKRIDEDDFADEE from the C Terminus of the protein sequence according to NP_783195.2; NP_006522.2.

Biochem/physiol Actions

Intraflagellar transport 88 (IFT88) is involved in cilia formation. It is linked to polycystic kidney disease. In mitosis, the protein has a crucial role in spindle orientation. IFT88 is downregulated in hepatocellular carcinoma.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
低风险生物材料
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Certificates of Analysis (COA)

Lot/Batch Number
7088P1

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Polaris, a Protein Involved in Left-Right Axis Patterning, Localizes to Basal Bodies and Cilia
Patrick D
Molecular Biology of the Cell (2001)
The cilia protein IFT88 is required for spindle orientation in mitosis.
Delaval B
Nature Cell Biology (2011)
Tg737 signaling is required for hypoxia-enhanced invasion and migration of hepatoma cells.
You N
Journal of Experimental & Clinical Cancer Research (2012)
The molecular biology of polycystic kidney disease
Noel S
Pediatric Nephrology (Berlin) (1998)

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