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Merck
CN

SAB2500878

Sigma-Aldrich

Anti-Renalase (AA 224-233) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-C10orf59, Anti-Chromosome 10 open reading frame 59, Anti-FLJ11218, Anti-HGNC:25641, Anti-Hypothetical protein LOC55328

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: suitable

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... C10orf59(55328)

General description

Renalase (RNLS) is an intracellular flavin adenine dinucleotide-dependent amine oxidase. This flavoprotein′s amino-terminal peptide sequence is necessary for FAD accommodation. It is secreted by the kidney into the blood. RNLS is also expressed in the heart, skeletal muscle and small intestine. The gene encoding this protein consists of nine exons and is localized on human chromosome 10q23.33.

Immunogen

Peptide with sequence C-VSIDNKKRNI from the internal region of the protein sequence according to NP_001026879.1; NP_060833.1.

Biochem/physiol Actions

Renalase (RNLS) modulates blood pressure and cardiac activities. It reduces circulating catecholamines. Patients with end-stage renal disease have reduced concentrations of renalase in the plasma.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Precautionary Statements

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
6747C2G2
2365P1
6747P2
6747P1

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Find documentation for the products that you have recently purchased in the Document Library.

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Renalase gene polymorphism is associated with increased blood pressure in preeclampsia.
Bagci B
Pregnancy hypertension (2016)
Renalase Secreted by Human Kidney HEK293T Cells Lacks its N-Terminal Peptide: Implications for Putative Mechanisms of Renalase Action.
Fedchenko V
Kidney & Blood Pressure Research (2016)
Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.
Xu J
The Journal of Clinical Investigation (2005)

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