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Merck
CN

SAB2501128

Anti-MS4A1 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-B1, Anti-Bp35, Anti-CD20, Anti-LEU-16, membrane-spanning 4-domains, subfamily A, member 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00211769

Key Documents

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biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

UniProt accession no.

P11836

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... MS4A1(931)

General description

Membrane spanning 4-domains A1 (MS4A1), also referred to as cluster of differentiation 20 (CD20), is expressed on the surface of human B lymphocytes and on a small subset of T cells. The 33-35kDa, non-glycosylated protein has four membrane-spanning domains with both the amino and carboxy termini of the protein localized to the cytoplasm, and a short 43 residue-extracellular segment. It is part of the membrane-spanning 4A gene family. The gene encoding MS4A1 is localized on human chromosome 11q12-13.

Immunogen

Peptide with sequence CQDQESSPIENDSSP, from the C Terminus of the protein sequence according to NP_068769.2; NP_690605.1.

Biochem/physiol Actions

Membrane spanning 4-domains A1 (MS4A1) or CD20 participates in the development and cell cycle progression in B-cells. It has been found to interact with proteins like adapter protein p75/80, CD40 and major histocompatibility complex class II proteins (MHC II). It may participate in Ca2+ influx across plasma membranes, maintenance of Ca2+ concentration and activation of B-cells. CD20 activates Src leading to rapid phosphorylation of phospholipase C-γ1 (PLC-γ1) and PLC-γ2, in turn activating caspase-3 signaling of apoptosis.

Features and Benefits

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Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
5140S2G2
5140S2
5140P1

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Aneuploidy should compromise cellular proliferation but paradoxically favours tumour progression and poor prognosis. Here, we consider this paradox in terms of our most recent observations of chemo/radio-resistant cells undergoing reversible polyploidy. The latter perform the segregation of two parental groups

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