SAB2501574
Anti-JAK2 (C-terminal) antibody produced in goat
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Janus kinase 2 (a protein tyrosine kinase), Tyrosine-protein kinase JAK2
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
flow cytometry: suitable
indirect ELISA: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... JAK2(3717)
General description
Janus kinase 2 (JAK2) encodes a tyrosine kinase which belongs to the Jak family of protein kinases. The gene encoding this protein is localized on human chromosome 9p24.
Immunogen
Peptide with sequence RVDQVRDNMAG, from the C-terminal region of the protein sequence according to AAC23653.1
Biochem/physiol Actions
Janus kinase 2 (JAK2) plays an important role in the activities of cytokine receptors. Overexpression of JAK2 results in neuroblastoma. Mutations in the gene have been linked to primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2?
Stefan Joos
International Journal of Cancer. Journal International Du Cancer, 103(4) , 489-495 (2003)
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
Evan Parganas
Cell, 93(3), 385- 395 (1998)
Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells.
Borriello L
Cancer Research, 77(18), 5142-5157 (2017)
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Shin DS
Cancer Discovery, 7(2), 188-201 (2017)
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