SAB2702133
Monoclonal Anti-CEP164 antibody produced in mouse
Synonym(s):
Cep164 Antibody, Cep164 Antibody - Monoclonal Anti-CEP164 antibody produced in mouse, NPHP15
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
13, monoclonal
Application:
ICC, IF, IP, WB
Citations:
4
biological source
mouse
Quality Segment
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
13, monoclonal
form
liquid
species reactivity
human
concentration
1 mg/mL
technique(s)
immunocytochemistry: suitable, immunofluorescence: suitable, immunoprecipitation (IP): suitable, western blot: 1:500-1:3000
isotype
IgG1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CEP164(22897)
General description
The centrosomal protein 164 (CEP164) is expressed at the distal ends of the mother centriole. This protein consists of an N-terminal WW domain and three coiled-coil regions. The CEP164 gene is located on the human chromosome at 11q23.3.
Immunogen
Human Cep164
Application
Monoclonal Anti-CEP164 antibody produced in mouse has been used in immunoblotting (5 μg/ml).
Biochem/physiol Actions
The centrosomal protein 164 (CEP164) plays an important role in the synthesis of the primary cilium. This protein interacts with several proteins during ciliogenesis such as Rabin-8, Tau tubulin kinase‐2 (TTBK2), coiled-coil domain containing 41 (CCDC41), and dishevelled (DVL). CEP164 protein is also involved in G2/M checkpoint and nuclear divisions. This protein is a key player in the DNA damage-activated ataxia telangiectasia mutated (ATM)/Rad3-related (ATR) signaling cascade since it is required for the proper phosphorylation of the histone family member X (H2AX), replication protein A (RPA), checkpoint kinase 1 and 2 (CHK1/2). Mutations in the CEP164 gene leads to a condition known as nephronophthisis (NPHP)‐related ciliopathies.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Phosphate-buffered saline, no preservative added.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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