SAB2702173
Monoclonal Anti-FANCD2 antibody produced in mouse
Synonym(s):
FACD, FAD, FAD2, FANCD
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
103
monoclonal
monoclonal
Application:
ELISA
western blot
western blot
Species reactivity:
human
Citations:
5
Technique(s):
ELISA: suitable
western blot: 1:500-1:3000
western blot: 1:500-1:3000
Uniprot accession no.:
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
103
monoclonal
form
liquid
species reactivity
human
concentration
1 mg/mL
technique(s)
ELISA: suitable
western blot: 1:500-1:3000
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FANCD2(2177)
Application
For WB: Use at a dilution of 1:500-1:3000. For ELISA: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the researcher.
Biochem/physiol Actions
Fanconi Anemia Complementation Group D2 (FANCD2) protein is one of at least six factors shown to be involved in the autosomal-recessive cancer-prone disorder, Fanconi Anemia (FA). FA group D has been shown to be comprised of two separate proteins, FANCD1 and FANCD2. Mutations in BRCA2 can cause FANCD1. FANCD2 has been shown to colocalize with BRCA1 in ionizing radiation-induced foci. FANCD2 is involved in genomic resistance to DNA cross-linking reagents, and the arrest of DNA synthesis following exposure to ionizing radiation. FANCD2 has been shown to directly interact with NBS1
Fanconi anemia complementation group D2 (FANCD2) is implicated in countering endogenous levels of replication stress, which is required for maintenance of genomic stability. FANCD2 plays a crucial role in fanconi anemia (FA) pathway. It is also involved in the regulation of human papillomavirus (HPV) replication. Overexpression of the gene has been observed in hepatocellular carcinoma (HCC). Thus, it can be considered as a potential biomarker for poor prognosis and therapeutic target for HCC.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
Fanconi anemia complementation group D2 (FANCD2) is encoded by the gene mapped to human chromosome 3p25.3.
Immunogen
Human FANCD2 fusion protein
Physical form
Phosphate-buffered saline, no preservative added.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication
Spriggs CC and Laimins LA
mBio, 8, e02340-e02316 (2017)
Localization of the Fanconi Anemia Complementation Group D Gene to a 200-kb Region on Chromosome 3p25.3
Hejna JA, et al.
American Journal of Human Genetics, 66, 1540-1551 (2000)
Constitutive role of the Fanconi anemia D2 gene in the replication stress response.
Tian Y, et al.
The Journal of Biological Chemistry, 292, 20184-20195 (2017)
Clinical Significance of FANCD2 Gene Expression and its Association with Tumor Progression in Hepatocellular Carcinoma.
Komatsu H, et al.
Anticancer Research, 37, 1083-1090 (2017)
Joshi Niraj et al.
Nucleic acids research, 45(14), 8341-8357 (2017-07-02)
Fanconi anemia (FA) is a recessive genetic disorder characterized by congenital abnormalities, progressive bone-marrow failure, and cancer susceptibility. The FA pathway consists of at least 21 FANC genes (FANCA-FANCV), and the encoded protein products interact in a common cellular pathway
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