SAB2702400
Anti-N-cadherin antibody produced in rabbit
affinity isolated antibody
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
99kDa
species reactivity
zebrafish
concentration
1mg/mL
technique(s)
immunohistochemistry: 1:100-1:500, western blot: 1:5,000-1:20,000
isotype
IgG
shipped in
wet ice
storage temp.
−20°C
General description
N-cadherin, also known as cadherin 2 (CDH2), is encoded by the gene mapped to human chromosome 18q11.2. N-Cadherin belongs to the cadherin family. It is highly expressed on the cell membrane of endothelium, nervous and muscular cells.
Immunogen
Recombinant protein encompassing a sequence within the center region of zebrafish N-cadherin.
Application
Suggested starting dilutions are as follows: WB: 1:5000-1:20000, IHC-Wm: 1:100-1:500. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Biochem/physiol Actions
Cadherins plays a vital role in cell-cell adhesion. N-glycosylation of N-cadherin is associated with the process of tumorigenesis especially in mammary gland, renal system and ovary. In addition, N-glycosylation helps in maintaining N-cadherin stability and facilitates glioma migration. Over expression of CDH2 gene was observed in tumor cells. It is known to induce the invasive and chemoresistant attributes to the cancer cells. Loss of expression of the gene was observed in adrenocortical carcinoma. Thus, it can be used as a molecular biomarker in various types of tumoral adrenocortical tissue.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Other Notes
Purification: Purified by antigen-affinity chromatography
Disclaimer
For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Endothelial cell-to-cell junctions
Dejana E, et al.
Faseb Journal, 9(10), 910-918 (1995)
Structure of the human N-cadherin gene: YAC analysis and fine chromosomal mapping to 18q11.2.
Wallis J, et al.
Genomics, 22(1), 172-179 (1994)
Qing Ma et al.
Journal of Cancer, 10(17), 3975-3984 (2019-08-17)
Lung adenocarcinoma (LAD) is the most common type of lung cancer with a high possibility of tumor relapse and metastasis. ENKUR (Enkurin) was originally identified as a potential regulator or effector of TRPC channels that directly binds to several TRPC