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Merck
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SAB3500242

Anti-DARC antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CADM3, Anti-Cell adhesion molecule 3, Anti-Duffy antigen, Anti-Fy glycoprotein, Anti-GpFy

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

Q16570

UniProt accession no.

Q16570

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DARC(2532)

General description

Duffy antigen/chemokine receptor (DARC) or atypical chemokine receptor 1 (ACKR1) is a membrane-bound protein. The gene encoding this chemokine receptor is localized on human chromosome 1q23.2.

Immunogen

DARC antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human DARC.

Biochem/physiol Actions

Duffy antigen/chemokine receptor (DARC) or atypical chemokine receptor 1 (ACKR1) functions as an antigen of the Duffy (Fy) blood group system. It has a role in the infection of red blood cells (RBCs) by Plasmodium vivax and the lysis of RBCs by Staphylococcus aureus. The protein has been shown to be downregulated in colorectal cancer.

Features and Benefits

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Physical form

Supplied in PBS with 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500242.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
40690701

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Isabelle Bouyssou et al.
Cell host & microbe, 31(12), 2080-2092 (2023-12-07)
Vivax malaria has long been thought to be absent from sub-Saharan Africa owing to the high proportion of individuals lacking the Duffy antigen receptor for chemokines (DARC) in their erythrocytes. The interaction between P. vivax Duffy-binding protein (PvDBP) and DARC is
Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans.
McManus KF
PLoS Genetics (2017)
High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry?based blood group genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles
Stefan Meyer
Transfusion (2014)
Staphylococcus aureus Targets the Duffy Antigen Receptor for Chemokines (DARC) to Lyse Erythrocytes.
Spaan AN
Cell host & microbe (2015)
Expression of Duffy antigen receptor for chemokines (DARC) is down-regulated in colorectal cancer.
Zhou S
Journal of Receptor and Signal Transduction Research (2015)

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