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Merck
CN

SAB3500479

Monoclonal Anti-IL-33 antibody produced in mouse

clone 12H6D12, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-Interleukin-33, Anti-NFHEV, Anti-Nuclear factor from high endothelial venules

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
12H6D12, monoclonal
Application:
ELISA (i), IHC, WB
Citations:
8

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

12H6D12, monoclonal

form

buffered aqueous solution

species reactivity

human, mouse

technique(s)

immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

NCBI accession no.

NP_254274

UniProt accession no.

O95760

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL33(90865)

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General description

Interleukin 33 (IL-33) is a potent immunomodulatory cytokine that belongs to the IL-1 family. It is highly expressed in endothelial venules, endothelial cells and epithelium. The gene encoding this protein is localized on human chromosome 9p24.1.

Immunogen

Mouse monoclonal IL-33 antibody was raised against the recombinant IL-33 protein.

Biochem/physiol Actions

Interleukin 33 (IL-33) functions as an extracellular cytokine and also translocates to the nucleus where it inhibits gene expression. IL-33 enhances the secretion of inflammatory cytokines and is associated with T-helper 2-type immune responses. It has been linked to chronic inflammatory diseases. High levels of IL-33 have been observed in the serum of patients with hepatocellular carcinoma and gastric cancer. Polymorphisms in this gene as well as its receptor are linked with atopic dermatitis, allergies and asthma.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
PM50410901

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Interleukin-33 promotes inflammatory cytokine production in chronic airway inflammation.
Shang J
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire (2015)
Tumor-infiltrating, interleukin-33-producing effector-memory CD8(+) T cells in resected hepatocellular carcinoma prolong patient survival.
Brunner SM
Hepatology (2015)
Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33.
Calven J
Journal of Translational Medicine (2015)
Esophageal Epithelial-Derived IL-33 Is Upregulated in Patients with Heartburn.
Sei H
PLoS ONE (2016)
Targeting the IL-1 family members in skin inflammation.
Jensen LE
Current Opinion in Investigational Drugs (2010)
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