SAB3500757
Anti-NKX2-1 antibody produced in rabbit
affinity isolated antibody
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
western blot
western blot
Species reactivity:
human, rat, mouse
Citations:
6
Technique(s):
ELISA: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
Product Name
Anti-NKX2-1 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
mol wt
41 kDa
species reactivity
human, rat, mouse
concentration
1 mg/mL
technique(s)
ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NKX2-1(7080)
Immunogen
Antibody was raised against a 16 amino acid peptide near the amino terminus of human NKX2-1.
Biochem/physiol Actions
NK2 homeobox 1(NKX2-1) has a role in the development of thyroid glands, lungs and brain. It modulates gene expression during embryogenesis. NKX2-1 has been found to be expressed in adenocarcinoma and small cell lung cancer. This protein acts as an immunohistological marker to distinguish between primary lung carcinoma and non-pulmonary cancer.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
NK2 homeobox 1 (NKX2-1) is expressed in epithelial cells of the thyroid gland and lungs. The gene encoding NKX2-1 is localized on human chromosome 14q13.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500757.
Physical form
Supplied at 1 mg/mL in PBS with 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Benign hereditary chorea related to NKX2. 1: expansion of the genotypic and phenotypic spectrum.
Peall K J, et al.
Developmental Medicine and Child Neurology, 56(7), 642-648 (2014)
Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas.
Klingen T A, et al.
Diagnostic Pathology, 8(1), 80-80 (2013)
Recurrent drop attacks in early childhood as presenting symptom of benign hereditary chorea caused by TITF1 gene mutations.
Rosati A, et al.
Developmental Medicine and Child Neurology, 57(8), 777-779 (2015)
Value of thyroid transcription factor (TTF)-1 for diagnosis and prognosis of patients with locally advanced or metastatic small cell lung cancer.
Misch D, et al.
Diagnostic Pathology, 10(1), 21-21 (2015)
Lara López-González et al.
Brain structure & function, 228(2), 537-576 (2023-01-05)
The ventromedial hypothalamic nucleus (VMH) is one of the most distinctive hypothalamic tuberal structures, subject of numerous classic and modern functional studies. Commonly, the adult VMH has been divided in several portions, attending to differences in cell aggregation, cell type
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