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SAB4200051

Anti-JUB (C-terminal) antibody produced in rabbit

Name: Anti-JUB (C-terminal) antibody produced in rabbit
Brand: SIGMA

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Ajuba

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, WB

Citations:

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Properties

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~57 kDa

species reactivity

human, mouse

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.0 mg/mL

technique(s)

indirect immunofluorescence: 10-20 μg/mL using P19 cells, indirect immunofluorescence: 5-10 μg/mL using HeLa cells and 10-20 μg/mL using P19 cells, western blot: 0.3-0.6 μg/mL using HEK-293T cell lysates expressing human JUB

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... JUB(84962)

Description

General description

JUB, also known as Ajuba, is encoded by the gene mapped to human chromosome 14q11.2. JUB is an adaptor/scaffolding protein and is a member of the zyxin family of cytosolic LIM proteins. The protein is characterized with three related tandem LIM domains at the C terminus associated with unique and distinctive N-terminal, or Pre LIM domains.

Application

Anti-JUB (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

Anti-JUB (C-terminal) specifically recognizes human and mouse JUB.

JUB mediates various cellular events. It plays a role in cadherin-mediated cell-cell adhesion and in cell migration. JUB is recruited to cadherin complexes through interaction with α catenin, and also influences the localization of p130Cas at focal adhesions and Rac1 activity during cell migration. Altered expression of the gene has been observed in human papillomavirus (HPV) virus.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Preparation Note

Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品

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Global Trade Item Number

SKU	GTIN
SAB4200051-25UL	04061837875304
SAB4200051-200UL	04061837875298