Anti-CYBB antibody produced in rabbit

CYBB (cytochrome b-245), belongs to the family of NADPH oxidases, that catalyze the generation of the superoxide ion. It is a six-transmembrane glycoprotein, that binds heme, flavin and NADPH. CYBB associates with membrane-bound p22^phox to assemble the heavy subunit of flavocytochrome b558, the catalytic component of phagocyte NADPH oxidase. It also associates with four cytosolic components p47^phox, p67^phox, p40^phox and Rac2 required for NADPH oxidase activity. Homologs of the NOX protein family include the catalytic subunits NOX1, NOX3-5, Duox1 and Duox2. NOX2/gp91^phox is expressed in neutrophils and phagocytes.

Anti-CYBB antibody produced in rabbit has been used in immunoblotting and western blotting.

CYBB (also known as cytochrome b-245) promotes neurotoxic activation of microglia, that play a central role during neuroinflammatory states and in amyotrophic lateral sclerosis (ALS). NOX1, NOX3-5, Duox1 and Duox2 plays important roles in redox-dependent cell signaling, inflammation and in neurodegenerative diseases. In ALS mice, deletion of either NOX1 or NOX2 gene has significantly slowed disease progression and improved survival.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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