Anti-DYX1C1 antibody produced in rabbit

The dyslexia susceptibility 1 candidate 1 (DYX1C1) gene is located near the DYX1 locus in the human chromosome 15q21. The encoded protein contains three tetratricopeptide repeat (TPR) domains. DYX1C1 is expressed in several tissues, including the brain, lungs and kidney. The protein resides in the nucleus of the cortical neurons and glial cells.

Anti-DYX1C1 antibody produced in rabbit is suitable for immunoblotting.

Anti-DYX1C1 specifically recognizes human DYX1C1.

The dyslexia susceptibility 1 candidate 1 (DYX1C1) gene is identified as a candidate gene implicated in dyslexia due to chromosomal translocations. The encoded protein is involved in neuronal migration and other developmental processes. It also functions as protein interaction modules. Knockdown of the gene DYX1C1 by RNA interference (RNAi) in rats causes a deficit in neuronal migration in the developing neocortex, auditory processing, and spatial learning, supporting the role of DYX1C1 in dyslexia. The protein is known to be implicated as a cancer biomarker in colorectal cancer.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing is not recommended. Storage in “frost-free” freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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