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Merck
CN

SAB4200152

Anti-Importin 7 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

Synonym(s):

Anti-IMP7, Anti-IPO7, Anti-RAN-BINDING PROTEIN 7, Anti-RANBP7

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-Importin 7 (C-terminal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~120 kDa

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 5-10 μg using lysates of human HEK-293 cells
western blot: 1-2 μg/mL using whole extracts of human HeLa cells

UniProt accession no.

Q9H2H9

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IPO7(10527)

Application

Anti-Importin 7 (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

Biochem/physiol Actions

Nucleocytoplasmic transport of proteins and RNAs is mediated through nuclear pore complexes (NPCs) and by karyopherins nuclear transport receptors (importins/exportins). Importins mediate either the nuclear import of a very diverse set of protein or RNA cargoes. The function of importins areregulated by the Ran G protein., Ran G protein stimulates the release of cargo from importins. Importins are implicated in anti-aggregation activity of highly basic cargo like histones and ribosomal proteins and in preventing their undesired interactions with other cellular components.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

In human cells, there are more than 20 members of the importins/exportins family. Importin 7 (also known as IPO7, RANBP7 and IMP7) has been identified as an importin for ribosomal protein L23a (rpL23a), histone H1, human immunodeficiency virus (HIV) reverse transcriptase complex and the zinc finger protein, EZI.

Immunogen

synthetic peptide corresponding to amino acids 943-957 of human Importin 7

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
108M4801
060M4810

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Identification of ZNF217, hnRNP-K, VEGF-A and IPO7 as targets for microRNAs that are downregulated in prostate carcinoma
Szczyrba J, et al.
International Journal of Cancer. Journal International Du Cancer, 132(4), 775-784 (2013)
Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms
Saijou E, et al.
Test, 282(44), 32327-32337 (2007)
Structural biology of nucleocytoplasmic transport
Cook A, et al.
Annual Review of Biochemistry, 76(3), 647-671 (2007)
Jaroslaw Szczyrba et al.
International journal of cancer, 132(4), 775-784 (2012-07-21)
In primary prostate cancer (PCa), a major cause of cancer-related death in men, the expression of various microRNAs (miRNAs) is deregulated. We previously detected several miRNAs, for example, miR-24 and miR-22, as significantly downregulated in PCa (Szczyrba et al., Mol
Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains
Jakel S, et al.
The Embo Journal, 21(3), 377-386 (2002)

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