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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
2
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~120 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 2.5-5.0 μg using HepG2 cell lysates, indirect immunofluorescence: 1.25-2.5 μg/mL using HEK-293T cells overexpressing human Importin 4, western blot: 1-2 μg/mL using HepG2 cell lysates
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... IPO4(79711)
General description
Importin 4 is a member of importin protein family. It is a 119 kDa protein.
Immunogen
synthetic peptide corresponding to a sequence at the N-terminal of human Importin 4
Application
Anti-Importin 4 (N-terminal) antibody produced in rabbit has been used in several immunochemical techniques including immunoblotting, immunoprecipitation and immunofluorescence.
Biochem/physiol Actions
Importins can mediate the nuclear import of a diverse set of protein or RNA cargoes. Importins were implicated in anti-aggregation activity of highly basic cargo like histones and ribosomal proteins and in preventing their undesired interactions with other cellular components. It has been identified as an import factor for ribosomal protein rpS3a, the vitamin D receptor (VDR) and the sperm transition protein transition protein 2 (TP2).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Related Content
Instructions
Involvement of importin-4 in the transport of transition protein 2 into the spermatid nucleus
Pradeepa MM, et al.
Molecular and Cellular Biology, 28(13), 4331-4341 (2008)
Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains
Jakel S, et al.
The Embo Journal, 21(3), 377-386 (2002)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4200168-200UL | 04061838035097 |