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SAB4200216

Sigma-Aldrich

Monoclonal Anti-Caveolin-1 antibody produced in mouse

enhanced validation

clone CAV1, tissue culture supernatant

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Synonym(s):
Anti-BSCL3, Anti-CAV1, Anti-CGL3, Anti-MSTP085, Anti-VIP21, Anti-caveolae protein, 22kDa
MDL number:
MFCD01633097
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

CAV1, monoclonal

form

buffered aqueous solution

mol wt

antigen 22 kDa

species reactivity

rat, human, mouse

enhanced validation

independent
Learn more about Antibody Enhanced Validation

technique(s)

immunohistochemistry: suitable
indirect immunofluorescence: 1:1000-1:2000 using human HUVEC or mouse 3T3 cells.
western blot: suitable

isotype

IgM

UniProt accession no.

Q03135

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CAV1(857)
mouse ... Cav1(12389)
rat ... Cav1(25404)

Related Categories

General description

Caveolin-1 (CAV1) is a multifunctional scaffolding protein, that has three exons. It is located on human chromosome 7q31.

Immunogen

synthetic peptide corresponding to a sequence at the N-terminal of human caveolin-1, conjugated to KLH.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Monoclonal Anti-Caveolin-1 antibody has been used in western blot analysis.

Biochem/physiol Actions

Caveolin-1 may play a major role in the growth and evolution of cancer. It participates in glucose metabolism. It may also participate in angiogenesis. Cav-1 helps to control the expression of glucose transporters.

Physical form

Culture supernatant solution containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Description
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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Margaret E Tome et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 38(12), 2209-2222 (2018-10-23)
P-glycoprotein (PgP) is the major drug efflux pump in human cerebral microvessels. PgP prevents pathogens, toxins and therapeutic drugs from entering the CNS. Understanding the molecular regulation of PgP activity will suggest novel mechanisms to improve CNS drug delivery. Previously
Ye Xiong et al.
Oncotarget, 8(15), 24902-24914 (2017-02-18)
As the most prevalent primary brain tumor, gliomas are highly metastatic, invasive and are characteristic of high levels of glial cell-line derived neurotrophic factor (GDNF). GDNF is an important factor for invasive glioma cell growth; however, the underlying mechanism involved
Expression of flotilin-2 and acrosome biogenesis are regulated by MiR-124 during spermatogenesis
Wu Y, et al.
PLoS ONE, 10(8), e0136671-e0136671 (2015)
Joshua Chuck Harrell et al.
Cancer research, 67(21), 10582-10591 (2007-11-03)
The lymphatic system is a common avenue for the spread of breast cancer cells and dissemination through it occurs at least as frequently as hematogenous metastasis. Approximately 75% of primary breast cancers are estrogen receptor (ER) positive and the majority
Adam C Midgley et al.
The Journal of biological chemistry, 290(18), 11218-11234 (2015-02-27)
Hyaluronan (HA) promotes transforming growth factor (TGF)-β1-driven myofibroblast phenotype. However, HA can also have disease-limiting activity. Bone morphogenetic protein-7 (BMP7) is an antifibrotic cytokine that antagonizes TGF-β1, and isolated studies have demonstrated that HA can both mediate and modulate BMP7
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