Anti-MAN1B1 antibody produced in rabbit

Mannosidase α class 1B member 1 (MAN1B1), also known as endoplasmic reticulum α 1,2 mannosidase I (ERManI), is an ER resident transmembrane protein that belongs to the glycosyl hydrolase family 47. The MAN1B1 gene is mapped to human chromosome 9q34.3.

Anti-MAN1B1 antibody produced in rabbit is suitable for immunoblotting.

Anti-MAN1B1 recognizes human MAN1B1.

Mannosidase α class 1B member 1 (MAN1B1) gene is implicated in N-glycan processing and endoplasmic reticulum (ER) quality control. The MAN1B1 protein primarily removes the middle branch mannose from mannonanose-di-(N-acetyl-D-glucosamine) (Man₉GlcNAc₂) to form mannooctaose-di-(N-acetyl-D-glucosamine (Man₈GlcNAc₂) isomer B, but at high local concentrations, as found in the ER quality control compartment, it further trims the carbohydrates to Man_5-6GlcNAc₂. Overexpression of the MAN1B1 gene increases mannose trimming and accelerates endoplasmic reticulum associated degradation (ERAD) of terminally misfolded glycoproteins.

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2–8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

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