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Merck
CN

SAB4200239

Sigma-Aldrich

Anti-Alpha4 antibody, Mouse monoclonal

clone 5F6, purified from hybridoma cell culture

Synonym(s):

Anti-IGBP1, Anti-Immunoglobulin-binding protein 1

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About This Item

MDL number:
MFCD02685945
UNSPSC Code:
12352203
NACRES:
NA.44

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

5F6, monoclonal

form

buffered aqueous solution

mol wt

antigen ~40 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

western blot: 1-2 μg/mL using whole extracts of mouse 3T3 or human HeLa cells

isotype

IgG1

UniProt accession no.

P78318

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IGBP1(3476)
mouse ... Igbp1(18518)

General description

α 4 is a phosphoprotein that is expressed in a wide range of tissues, including pancreas, lymph node, thymus, kidney, leukocytes, fetal liver, heart, and brain. This phosporpotein associates with protein phosphatases 2A, 4, and 6 to regulate the rapamycin-sensitive pathway mediated by FRAP. α4 also binds to MID-1 and subsequently modulates PP2A function . Monoclonal Anti-α4 antibody is specific for human and mouse α4 (approx. 40 kDa).

Immunogen

mouse Alpha4 fusion protein. The corresponding sequence shares 80% homology with human Alpha4.

Application

Monoclonal Anti-α4 antibody is suitable for use in western blot (1-2 μg/mL using whole extracts of mouse 3T3 or human HeLa cells).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
100M4887

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J Chen et al.
Biochemical and biophysical research communications, 247(3), 827-832 (1998-07-02)
Protein phosphatases participate in the regulation of a variety of cellular processes. Control of their enzymatic activity and specificity is made possible largely by an array of regulatory subunits. Novel serine/threonine phosphatases--PP4 and PP6 in human cells--have been discovered recently
Haijuan Du et al.
PloS one, 6(12), e28877-e28877 (2011-12-24)
Alpha4 is a regulatory subunit of the protein phosphatase family of enzymes and plays an essential role in regulating the catalytic subunit of PP2A (PP2Ac) within the rapamycin-sensitive signaling pathway. Alpha4 also interacts with MID1, a microtubule-associated ubiquitin E3 ligase
Marketa Koncicka et al.
PloS one, 15(4), e0229781-e0229781 (2020-04-29)
Lamin C2 (LMN C2) is a short product of the lamin a gene. It is a germ cell-specific lamin and has been extensively studied in male germ cells. In this study, we focussed on the expression and localization of LMN
M Onda et al.
Genomics, 46(3), 373-378 (1998-01-27)
To study the function of the B cell signal transduction molecule alpha 4 (IGBP1), we isolated a human alpha 4 (IGBP1) gene that has sequence similarity to the yeast protein (TAP42) involved in the rapamycin-sensitive signal transduction pathway. The human

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