Anti-SIRT6 antibody, Mouse monoclonal

Monoclonal Anti-SIRT6 (mouse IgG2b isotype) is derived from the hybridoma SIRT6-4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to the N-terminal region of human Sirt6 conjugated to KLH. Sirtuin 6 (Sirt6) belongs to the mammalian Sir2 gene family. It is a nuclear, chromatin-associated protein. Sirt6 is broadly expressed with the highest levels in muscle, brain and heart.

synthetic peptide corresponding to the N-terminal region of human Sirt6 (GeneID: 51548), conjugated to KLH.

Monoclonal Anti-SIRT6 antibody produced in mouse has been used in immunoblotting.

Sirtuin 6 (Sirt6) plays a key role in DNA repair and maintenance of genomic stability in cells. Sirt6 is enzymatically inactive as a Nicotinamide adenine dinucleotide (NAD⁺) -dependent protein deacetylase but displays auto-adenosine triphosphate (ADP)-ribosyl transferase activity. Loss of Sirt6 leads to the development of an acute degenerative aging-like phenotype.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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