Anti-PLEKHA7 (C-terminal) antibody produced in rabbit

Pleckstrin homology domain-containing family A, member 7 (PLEKHA7) protein contains WW, pleckstrin homology (PH) and coiled-coil (CC) domains. PLEKHA7 protein is a part of cadherin-based protein complex in mammalian epithelial cells. The PLEKHA7 gene is mapped to human chromosome 11p15.2-p15.1.

synthetic peptide corresponding to the C- terminal region of human PLEKHA7 conjugated to KLH. The corresponding sequence differs by a single amino acid in mouse.

Anti-PLEKHA7 (C-terminal) antibody produced in rabbit is suitable for immunoblotting and immunoprecipitation.

Anti-PLEKHA7 (C-terminal) recognizes human PLEKHA7.

Pleckstrin homology domain-containing family A, member 7 (PLEKHA7) protein via the cadherin-based protein complex is involved in anchoring the microtubule minus ends to the zonula adherens (ZA). This is essential for the biogenesis of specialized junction. PLEKHA7 binds directly to E-cadherin and cadherin associated protein p120-catenin complexes and appears to be necessary for recruiting NEZHA to the ZA.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions shouldbe discarded if not used within 12 hours.

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