SAB4200307
Anti-RAMP2 (N-terminal) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody
Synonym(s):
Anti-Receptor activity modifying protein 2
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About This Item
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
mol wt
antigen ~20 kDa
species reactivity
human
concentration
~1.5 mg/mL
technique(s)
western blot: 1.5-3.0 μg/mL using cell lysates of HEK-293T cells over expressing human RAMP2
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RAMP2(10266)
General description
The receptor activity-modifying protein 2 (RAMP2) gene is mapped to human chromosome 17q21.2. RAMPs 1-3 are a novel class of single transmembrane accessory proteins. While mammalian RAMPs 1-3 significantly differ in sequence homology and tissue distribution, they possess comparable structure, with a long extracellular N-terminus, a single transmembrane domain, and a short cytoplasmic C-terminus.
Immunogen
synthetic peptide corresponding to a sequence located near the N-terminal of human RAMP2, conjugated to KLH
Application
Anti-RAMP2 (N-terminal) antibody produced in rabbit is suitable for immunoblotting.
Biochem/physiol Actions
Anti-RAMP2 (N-terminal) specifically recognizes human RAMP2.
Receptor activity-modifying proteins (RAMPs 1-3) are essential for the function of various G-protein coupled receptors (GPCRs). Preferential adrenomedullin (AM) binding is established by the interaction between calcitonin receptor-like receptor (CLR or CRLR) and RAMP2. Tissue-specific analysis of the human and mouse transcriptomes shows that the formation of a functional AM receptors is possible with most CLR being complexed with RAMP2. RAMP2 is required for the transport of AM receptor and for presenting it at the cell surface as a mature glycoprotein. RAMP2 is essential for angiogenesis and vascular integrity, and for lymphatic vascular development during embryogenesis. RAMPs represent as potential targets for the treatment of human diseases related to either AM or calcitonin gene-related peptide (CGRP) physiology.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Yuka Ichikawa-Shindo et al.
The Journal of clinical investigation, 118(1), 29-39 (2007-12-22)
Adrenomedullin (AM) is a peptide involved both in the pathogenesis of cardiovascular diseases and in circulatory homeostasis. The high-affinity AM receptor is composed of receptor activity-modifying protein 2 or 3 (RAMP2 or -3) and the GPCR calcitonin receptor-like receptor. Testing
Zainab Asrar et al.
Molecular phylogenetics and evolution, 66(3), 737-747 (2012-11-13)
Susumu Ohno's idea that modern vertebrates are degenerate polyploids (concept referred as 2R hypothesis) has been the subject of intense debate for past four decades. It was proposed that intra-genomic synteny regions (paralogons) in human genome are remains of ancient
Kenji Kuwasako et al.
The Journal of biological chemistry, 281(11), 7205-7213 (2006-01-18)
Receptor activity-modifying proteins (RAMPs) enable calcitonin receptor-like receptor (CRLR) to function as a calcitonin gene-related peptide receptor (CRLR/RAMP1) or an adrenomedullin (AM) receptor (CRLR/RAMP2 or -3). Here we investigated the functions of the cytoplasmic C-terminal tails (C-tails) of human RAMP1
Kimberly L Fritz-Six et al.
The Journal of clinical investigation, 118(1), 40-50 (2007-12-22)
The lymphatic vascular system mediates fluid homeostasis, immune defense, and tumor metastasis. Only a handful of genes are known to affect the development of the lymphatic vasculature, and even fewer represent therapeutic targets for lymphatic diseases. Adrenomedullin (AM) is a
Carrie Gibbons et al.
Molecular endocrinology (Baltimore, Md.), 21(4), 783-796 (2006-10-21)
Adrenomedullin (AM) is a 52-amino-acid multifunctional peptide that circulates in the plasma in the low picomolar range and can exert a multitude of biological effects through an autocrine/paracrine mode of action. The mechanism by which AM transduces its signal represents
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